Mol Med Rep. 2015 Aug;12(2):2689-94. Estroven Complete is an all-natural dietary supplement that claims to help relieve the symptoms of menopause by up to 60% as it contain special extract[1] called 'Rhapontic Rhubarb Root Extract'. Its most important active ingredients are the hydroxystilbenes (see stilbenes below) rhaponticin (fluoresces blue in UV light), rhapontigenin, deoxyrhapontigenin, substances with oestrogenic effects. Furthermore deoxyrhaponticin, chrosophanic acid, oxalic acid and tanning . The dry extract from the roots of rhapontic rhubarb (Rheum rhaponticum) belongs to the group of phytopharmaceuticals. The dosage of ERr 731 (rhapontic rhubarb) is 1 tablet/day. Is Rhapontic rhubarb root extract ERr 731 Safe? Although the above species are well-known vegetables, scientific interest in these plants is a . It helps relieve night sweats and hot flushes while boosting your energy levels and improving sleep. Rhubarb can cause some side effects such as stomach and intestinal pain, watery diarrhea, and uterine contractions. Is black cohosh good for night sweats? Environ Toxicol. Design: Three hundred sixty-three menopausal women with menopausal . 17 Estrogen receptor b, which mediates the anxiolytic and antidepressant effects of estrogen, has been suggested to alleviate menopausal symptoms, including depression and anxiety. Subjects have reported symptom . 3,7,8 These rhubarb compounds bind to the beneficial ER-beta receptorsthe receptors more predominant in skin, brain, bone, heart, and other body areas that suffer during the menopausal estrogen decline. . Benefits of taking Rhubarb Extract supplements: 1.Weight loss The work reviews available literature (until March, 2020) on phytochemical profile, ethnomedicinal recommendations, biological activities, pharmacological uses and future prospects for therapeutic applications of Rheum rhabarbarum L. (garden rhubarb) and Rheum rhaponticum L. (rhapontic rhubarb). For Chinese rhubarb in a crude powder form, a common dosage is 10-30 g/day. Antimetastatic effects of Rheum palmatum L. extract on oral cancer cells. The latter contain a lot of oxalic acid, which can have lethal consequences if consumed in large doses. Rhubarb resembles a celery stalk only it has a pale green or pink color and is sour to . WHAT IS RHUBARB ROOT? However, it gained popularity during the 90s when it . Find patient medical information for rhubarb root extract oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse . Women who have -- or have had -- breast cancer or uterine cancer. The efficacy of ERr 731(), a commercially available extract isolated from Rheum rhaponticum, in terms of menopausal complaints like hot flushes, depression, anxiety and vaginal dryness has been proven in a two-year clinical study. Since discovering its purpose, millions use the extract to relieve inflammation, menopausal symptoms, fever, sepsis, and constipation. Rhubarb is unsafe for children. Rhubarb is LIKELY SAFE when the root is consumed as food. In anthroposophic medicine, rhapontic rhubarb root has been used for years as an ointment - nowadays also pessaries - for dry mucous membranes in the urogenital tract, to good effect and well . The net net for Siberian Rhubarb and cancer is this: ERa has been shown to be implicated in uterine hyperproliferation and the maintenance of breast cancer, whereas in tissues where both ER subtypes are expressed, the ERb subtype acts as a negative regulator of ERa, offering protection against hyperproliferation and carcinogenesis. Rhapontic Rhubarb Root Extract For Menopause And Weight Loss 10:1. Research shows evidence for the effectiveness of this plant in treating menopause symptoms. The phase IV clinical study analyzes which people take Rhubarb and have Hypothyroidism. Objective: To demonstrate the efficacy and tolerability ofERr 731 in menopausal women in everyday practice. However, the molecular basis of its clinical effectiveness remains obscure. It is created by eHealthMe based on reports of 152 people who have side effects while taking Rhubarb from the FDA, and is updated regularly. A retrospective study on the onset of menopause after chemotherapy: Analysis of data extracted from the Jean Perrin Comprehensive Cancer Center Database concerning 345 young breast cancer patients diagnosed between 1994 and 2012. Essiac also contains red clover, whose isoflavones have estrogenic properties. component. Rhubarb is also dangerous for pregnant and breast-feeding women. There is information that one 4-year-old boy died after eating rhubarb leaves. Lu K, Zhang C, Wu W, Zhou M, Tang Y, Peng Y. Rhubarb extract has a protective role against radiation-induced brain injury and neuronal cell apoptosis. Since the beginning of the 1990s, ERr 731 , an extract isolated from the roots of the Siberian rhubarb ( Rheum rhaponticum ), has been used regularly for the treatment of women suffering from oligomenorrhoea or amenorrhea (trade names Phyto-Strol , Mller-Gppingen and femi-loges , Loges). been recommending a purified and standardized extract of Siberian rhubarb (Rheum rhaponticum L.) known as ERr 731 since 1993. Although they sound similar, Siberian rhubarb root is not the same species as garden rhubarb, a vegetable commonly used for food. Women who have endometriosis. People with liver disease, a high risk of stroke or blood clots, or seizure disorders. Siberian rhubarb, also known as rhapontic rhubarb, is an extract from the roots of a plant called Rheum rhaponticum. It also relieves you of mental exhaustion . A dry extract from the roots of rhapontic rhubarb (extract Rheum rhaponticum (L.); ERr) has been commercially available in Germany for over two decades to treat menopausal symptoms. Chinese research is investigating Rhubarb's ability to possibly inhibit cancer cells. The root of Siberian rhubarb is rich in hydroxystilbene compounds including rhaponticin and desoxyrhaponticin. Rhubarb refers to a plant species in the Rheum family with roots in India, China, Turkey, and Iran. Clinical studies have demonstrated that 1 tablet (4 mg) daily of ERr 731 offers significantly effective relief vs. placebo for the 11 most common menopausal symptoms, including hot flushes. This plant has been around for centuries and originates back to Northern and Central Asia. Estroven. Based on current research, black cohosh is most likely to relieve symptoms related to reductions or . Estroven Menopause Relief Weight Management.. Dohou J, Mouret-reynier MA, Kwiatkowski F, et al. 2017 Oct;32(10):2287-2294. 1. Background: The special extract ERr 731 from the roots of rhapontic rhubarb has been in widespread use in Germany since 1993, and the current regulations have required an evaluation of its risk:benefit ratio in daily use. Rhubarb can easily make constipation or diarrhea worse . Researchers found 12 weeks of treatment with a pill containing extract of Rheum rhaponticum, the vegetable more commonly known as rhubarb, significantly reduced the frequency and severity of. Further a recent preclinical study excluded unwanted side effects on the endometrium by showing a lack of stimulation of proliferation marker genes by ERr 731 . Dicalcium Phosphate - This is used as an inactive ingredient in supplements . Rhapontic Rhubarb Root Extract - This is a plant which can only be found in the Rila Mountain Range in south-western Bulgaria. Children under 18. This article reviews the in vitro and in vivo data of its estrogenic actions . Clinical trials used doses ranging from 50 mg to 50 g/day, depending on the disease, type of extract, and other factors. The doses for rhubarb widely vary. Palm-leaf rhubarb and Tanggut-rhubarb medicinal materials are called northern rhubarb and are mainly produced in Qinghai, Gansu, Sichuan and other . The proprietary Siberian rhubarb root extract does not contain estrogen but appears to be a selective ERb agonist based on in vitro data. It is the anthraquinones that contribute to the laxative and purgative properties of Rhubarb, yet the tannin content helps balance those properties, and even stops diarrhea. Since 1993, ERr 731 , an extract isolated from the roots of rhapontic rhubarb, has been used regularly for the treatment of women suffering from oligomenorrhoea or amenorrhea (trade names. Turkish rhubarb root ( Rheum palmatum ), an herb related to common rhubarb, is a component of Essiac tea, a herbal tea sometimes used as a cancer treatment, primarily for prostate cancer, but also for breast cancer. The rhubarb extract is the dried root and rhizome extracts of the Polygonaceae plant rhubarb, tangute rhubarb or medicinal rhubarb. However, the molecular basis of its clinical effectiveness remains obscure. Chen YY, Hsieh MJ, Hsieh YS, et al. Introduction of Rhapontic Rhubarb Root Extract. It is POSSIBLY SAFE for most adults when taken by mouth in medicinal amounts for up to 3 months. A dry extract from the roots of rhapontic rhubarb (extract Rheum rhaponticum (L.); ERr) has been commercially available in Germany for over two decades to treat menopausal symptoms. It includes rhaponticin and desoxyrhaponticin, which are able to stimulate estrogen receptors.